The DNA binding property of PML/RARA but not the integrity of PML nuclear bodies is indispensable for leukemic transformation.
PML/RARA is the oncoprotein driving acute promyelocytic leukemia (APL).It suppresses genes expression by recruitment of a number of transcriptional repressors, resulting in differentiation block Hamper and malignant transformation of hematopoietic cells.Here, we found that mice primary hematopoietic progenitor cells (HPCs), transduced by DNA-bindin